Liverpool welcome Arsenal to Anfield for the second time already this season on Wednesday night as two of the Premier League's 'big six' do battle for a place in the quarter-finals of the EFL Cup.

The Reds beat Unai Emery's side 3-1 in August, one of nine wins from their opening 10 league games which has seen them make the joint-best start in the competition's history.

Liverpool are also the most successful club in the annals of the EFL Cup with eight victories, although the last of those came in 2012 and they have not picked up a single piece of domestic silverware since then.

Here, Sports Mole looks at how Jurgen Klopp could line his side up as they try to take another step towards ending that drought.

Out: Xherdan Shaqiri (calf), Nathaniel Clyne (knee)
Doubtful: Mohamed Salah (ankle), Virgil van Dijk (dead leg), Joel Matip (knee)

> Click here for Liverpool's latest injury and suspension news ahead of this match

Liverpool have injury doubts over arguably the two highest-profile players, and neither Mohamed Salah nor Virgil van Dijk are likely to be risked for this game as a result.

Both are expected to be available if needed, with Salah taking part in training on Monday following his 85th-minute withdrawal due to an ankle injury on Sunday and Van Dijk only suffering from a dead leg, but Klopp will take the opportunity to hand the duo a rest.

Wednesday's match will also come too soon for Joel Matip, which means that Dejan Lovren and Joe Gomez are likely to be the centre-back partnership in what is expected to be a much-changed team.

Klopp may stop short of handing the likes of Harvey Elliott and Curtis Jones starts as he did in the last round against MK Dons, but there should be opportunities for a handful of youngsters to gain some more first-team experience either form the start or off the bench.

Fringe players such as Adam Lallana, Divock Origi and Naby Keita will be hopeful of a run-out, while Alex Oxlade-Chamberlain is expected to start following his Champions League brace last week.

James Milner starred at left-back in the previous round and could be handed defensive duties again, while in goal Adrian will come in for Alisson Becker having already enjoyed more first-team football than he might have expected since his summer move.

> Click here to see how Arsenal could line up for this contest