Ernesto Valverde's side sit seven points clear of second-placed Atletico Madrid at the summit and will enter the match off the back of a 5-1 win over Lyon in the second leg of their last-16 Champions League tie, which saw them book their spot in the quarter-finals of the competition.
It is now 15 games since Barca last lost in the league, but that defeat came against their opponents this weekend, who recorded a 4-3 victory at Camp Nou back in November.
The treble is very much on for Barca as they will also face Valencia in the final of the Copa del Rey, but their attention this weekend will be on overcoming a dangerous Betis in Seville.
Here, Sports Mole takes a look at how Valverde's side could line up on Sunday night.
Rafinha and Thomas Vermaelen remain on the sidelines for Barca, and the pair have been joined by Ousmane Dembele, who picked up a hamstring injury against Lyon.