The Merseyside giants missed out on the Community Shield courtesy of a penalty-shootout defeat to Manchester City, but Jurgen Klopp will be confident that his team can get the better of their fellow Premier League side on Wednesday night.
Liverpool head into this encounter having recorded a 4-1 victory over Norwich City in their top-flight opener on Friday night, a match held almost two days ahead of Chelsea's defeat at Manchester United.
Here, Sports Mole takes a look at how the Champions League winners could line up on their return to Istanbul.
As a result of Alisson sustaining a significant calf injury in the game against the Canaries, Adrian will come into the team to make his first start since replacing Simon Mignolet as the Brazilian's deputy.
However, aside from long-term absentee Nathaniel Clyne, Klopp should be able to select from the remainder of his first-team squad, while also taking into consideration their league meeting at Southampton on Saturday afternoon.
Having been left on the substitutes' bench on Friday night, Sadio Mane should be recalled to the first XI as Klopp looks to improve the match fitness of the Senegal international.