The Seagulls will be encouraged by their performances against other big teams already this season, most notably a 3-2 victory over City's local rivals Manchester United last month.
That result remains Brighton's only win of the season, though, and they have since ended up pointless from matches against Liverpool and Tottenham Hotspur despite good displays.
Here, Sports Mole looks at how Brighton could line up at the Etihad.
Brighton are missing Stephens due to a hamstring strain, so Beram Kayal is likely to come in for his first Premier League start of the season.
One player who could be in line to return is Pascal Gross, although the midfielder will face a late fitness test to determine whether he has fully recovered from an ankle injury.
> Click here to see how Man City could line up for this fixture.
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