Wednesday's contest comes just three days after Man City were forced to go through extra time and penalties at Wembley, though, and injuries also took their toll on Pep Guardiola's side at the weekend.
Here, Sports Mole looks at how the hosts could line up.
Guardiola is the last manager in the Premier League who can complain about squad depth, but even his resources could be stretched following injuries to Fernandinho and Aymeric Laporte at Wembley.
The City boss suggested in his post-match press conference that both could be sidelined for at least four games, with Fernandinho seemingly a particularly big loss considering his absence earlier in the campaign coincided with back-to-back shock defeats.
Guardiola will no doubt want to rotate after going the distance on Sunday, but with six outfield players either injured or doubtful he may be forced to field the likes of Kevin De Bruyne, David Silva and Sergio Aguero once again.
Raheem Sterling and the relentless Bernardo Silva may be rested with Leroy Sane and Riyad Mahrez waiting in the wings, though, while Danilo is an option to replace Kyle Walker at right-back.
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