Manchester City are waiting to learn the extent of Aymeric Laporte's knee injury after the defender was carried off in Saturday's convincing defeat of Brighton.
Laporte left the field on a stretcher after mistiming a challenge on Adam Webster late in the first half of the champions' 4-0 victory at the Etihad Stadium.
Manager Pep Guardiola admitted after the game the situation "doesn't look good" but a full prognosis was still to be delivered.
The Seagulls have collected four points in four games.
Potter said: "It's going to be a challenge, it's going to be hard, and we know that.
"It's the top league in world football but we're going to be positive and try to develop our game.
"We need to get results as well but in terms of what the players have been doing, I can't ask any more from them."