Pep Guardiola's side currently sit two points behind Liverpool but have a game in hand over their title challengers and could take another step towards a potential quadruple by recording a 13th consecutive victory.
Cardiff were harshly denied three points against Chelsea on Sunday, but they know that a trip to the Etihad Stadium is a completely different proposition as the possibility of relegation becomes all the more likely.
Here, Sports Mole looks at how Man City could line up for the visit of the Bluebirds.
Rotation is anticipated to be the order of the day for Man City over the next few weeks as they continue to challenge on all fronts, so changes are expected from the weekend win over Fulham.
Sergio Aguero has been ruled out by Guardiola after limping off on Saturday so Gabriel Jesus will lead the line, and it could be an entirely different front three with Leroy Sane and Riyad Mahrez hoping to benefit from the changes.
The likes of Danilo and John Stones will also be hopeful of coming back into the team after being left on the bench at the weekend, while Benjamin Mendy and Vincent Kompany could further bolster City's defensive options by returning from injury.
Mendy is unlikely to come straight back into the side after another significant absence, though, meaning that Oleksandr Zinchenko is expected to start at left-back once again.
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