Last Wednesday's first leg at Old Trafford finished 1-0 to Barcelona, with United failing to register a single shot on target.
Of the 70 previous occasions a side has won a Champions League knockout tie first leg away from home, just four have been eliminated, though one exception to the norm was United's triumph in Paris last month.
Ahead of their trip to Camp Nou, Sports Mole looks at how Man United could line up.
Shaw's own goal in the first leg is the difference between the sides at the midway point in the tie, and the left-back will play no part in Catalonia after incurring an automatic ban for picking up three yellow cards.
Ole Gunnar Solskjaer has the option of using Darmian in that position, but he has only played twice in 2019. Ashley Young produced a poor display in the first leg and may lose his place to Diogo Dalot, who has grown in confidence.
Speaking after the 2-1 win over West Ham United on Saturday, Solskjaer suggested that Scott McTominay and Marcus Rashford - two of five players rested from the Barca match - will be restored to the starting lineup on Tuesday.