A run of four matches without a win in the top flight leaves United with little left to play for on the face of it, as they can no longer finish in the top four.
Ole Gunnar Solskjaer took the decision to integrate a number of young players into first-team training this week, but the Norwegian may still elect to field an experienced side against his former club to avoid further embarrassment.
Ahead of the visit of Cardiff, Sports Mole looks at how the Red Devils could line up.
Solskjaer has revealed that he plans to give Antonio Valencia a special send-off in his final match as a United player, possibly meaning a rare start for the long-serving wideman.
Angel Gomes, James Garner, Greenwood and Tahith Chong are among those to have trained with the first team this week, and the latter - who has already been used four times this season - is in line for a start.
In the likely absence of Lukaku up top, Marcus Rashford - one of just a few United players able to hold their head up high this term - appears certain to lead the line.