United face the unwelcome reality that either Man City or Liverpool will lift the title this season, but their role in the destination of the trophy will be of secondary importance to their own need for victory to boost their top-four hopes following a dreadful run of form.
City know that victory in all of their remaining games will be enough for them to defend the title, but anything less than all three points at Old Trafford would leave things in the hands of Liverpool with only three matches left.
Here, Sports Mole selects its strongest combined XI from both squads, using only players available on Wednesday.
It is no surprise to see Man City dominate this XI, particularly given the recent form of both teams, but perhaps the most contentious selection comes in goal where Ederson edges out David de Gea for the gloves.
De Gea has undoubtedly been one of the world's best for years now, but he made a howler in the Champions League against Barcelona and perhaps should have done better with two long-range strikes in Sunday's 4-0 defeat at the hands of Everton. It is now 11 games since United kept a clean sheet, whereas only Alisson Becker has kept more than Ederson in the Premier League this season.
Right-back has been something of a problem area for United of late, making Kyle Walker's selection a simple one ahead of the likes of Diogo Dalot, Ashley Young and Victor Lindelof, the latter of whom has filled in there for United in the past two games.
It is also a relatively easy decision to have two Man City central defenders, although the difficulty comes in selecting which two. Nicolas Otamendi and Vincent Kompany could both stake a claim for a place, but we have gone for John Stones and Aymeric Laporte, who have generally been Guardiola's preferred centre-back pairing for the majority of the season when fit.
If there is a weakness in this Man City side it arguably comes at left-back due to the injury problems suffered by Benjamin Mendy, and he is yet to rediscover his best form since returning from another lengthy absence. Oleksandr Zinchenko has filled in admirably, but Luke Shaw - available again on Wednesday following a two-match ban - gets the nod as the first United player to make the team.
Paul Pogba is the only other United representative in this XI despite his own personal dip in form during United's recent slump, although had Kevin De Bruyne been fit for the champions then Pogba's place in the team would be under serious threat.
Ilkay Gundogan provides further competition in midfield, but for now David Silva and Fernandinho remain above him in the pecking order. Fernandinho is a clear choice ahead of Nemanja Matic as the holding midfielder, while the evergreen Silva has helped Man City make light of De Bruyne's absences this season.
The quality of the Man City front three is highlighted by the fact that they have all been nominated for the PFA Player of the Year award, not to mention keeping the likes of Leroy Sane, Riyad Mahrez and Gabriel Jesus out of the team on a weekly basis.
Raheem Sterling has 17 goals and nine assists in the Premier League this season and is one of the frontrunners for the individual award alongside Liverpool's Virgil van Dijk, while Sergio Aguero's stats are even better with 19 goals and eight assists.
Fewer would have expected such a major contribution from Bernardo Silva this term, but the Portuguese forward has established himself as arguably Guardiola's most trusted player and is now one of the first names on the teamsheet for City - which is more than enough to earn him a place in this XI ahead of the likes of Marcus Rashford, Jesse Lingard and Romelu Lukaku.