The Lilywhites are within 180 minutes of a place in the June 1 final at the Wanda Metropolitano after overcoming Borussia Dortmund and Manchester City in the first two knockout rounds.
Spurs have lost three of their last four games in all competitions, albeit with a 4-3 reverse in the quarter-final second leg against domestic rivals City enough to take them through to this last-four showdown with Dutch giants Ajax.
Here, Sports Mole looks at how Mauricio Pochettino could set his side up for the contest.
Pochettino is without top scorer Kane and stand-in forward Son for Tuesday's match through injury and suspension respectively.
After being rested for the 1-0 loss to West Ham United at the weekend, meanwhile, Jan Vertonghen and Kieran Trippier should be restored in midweek, but Pochettino is keeping his options with regards to whether it will be a three or four-man backline.
Winks is expected to miss out with a groin complaint and Sissoko is also a big loss in the engine room, though Christian Eriksen has proved this season that he is more than capable of operating in a deeper midfield position.