The two sides played out an instant classic in the Champions League on Wednesday night, when City won a tumultuous affair 4-3 but were knocked out courtesy of the away-goals rule.
Another setback on Saturday could potentially see the Premier League title slip out of their grasp too, although victory would lift them back above Liverpool at the top of the table.
Here, Sports Mole rounds up City's latest injury and suspension news ahead of this weekend's crucial contest.
MANCHESTER CITY'S INJURY LIST
Status: Slight doubt
Type of injury: Thigh
Possible return date: April 20 (vs. Tottenham)
Pep Guardiola hinted that Oleksandr Zinchenko was pushing to be in contention last weekend, but he has not featured in either matchday squad since. The Ukrainian is expected to be available for selection on Saturday, though.
Type of injury: Achilles
Possible return date: Unknown
Claudio Bravo has been sidelined since August and may not make it back before the end of the season despite continuing to make progress in his recovery from an Achilles injury.
MANCHESTER CITY'S SUSPENSION LIST
Man City have no suspension issues ahead of this game.
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