The New York Giants lost their second consecutive game to end their chances of winning the NFC East division.
The Baltimore Ravens beat the reigning Super Bowl champions 33-14 to seal the AFC North title.
Eli Manning, the least-sacked starting quarterback in the NFL, was brought down three times by the Ravens defence, completing just 150 passing yards.
Ray Rice, Torrey Smith and Joe Flacco all found the end zone for Baltimore, while Justin Tucker was called on to add four field goals.
The win ends a three-game losing streak for the Ravens.
The loss means the Giants can only secure a wildcard spot in the post-season, as they have a worse divisional record than both the Washington Redskins and the Dallas Cowboys.
