The Los Angeles Rams extended their winning start to the NFL season to seven games with a 39-10 victory against the San Francisco 49ers.

Los Angeles, the NFL’s only unbeaten team, improved to 7-0 thanks to three more touchdowns from running back Todd Gurley and four sacks from defensive tackle Aaron Donald.

Gurley rushed into the end zone twice and caught one of quarterback Jared Goff’s two touchdown passes in a dominant road display.

The Kansas City Chiefs responded in style to their first defeat of the season as they blew away the Cincinnati Bengals 45-10.

Running back Kareem Hunt grabbed a hat-trick of touchdowns while star quarterback Patrick Mahomes threw for 358 yards and four touchdowns.

Chiefs improved to 6-1 and have scored at least 30 points in all but one of their seven games.

The Bengals remain top of the AFC North, though, as the Baltimore Ravens slipped to a dramatic 24-23 defeat to the New Orleans Saints.

The Saints clung on for victory as Ravens kicker Justin Tucker – trying to take the game into overtime – missed an extra-point attempt for the first time in his NFL career.

Saints quarterback Drew Brees earlier threw the 500th touchdown pass of his career.

The New England Patriots are 5-2 after they held on for a battling 38-31 win over the Chicago Bears.

A topsy-turvy affair marked by mistakes from both teams came down to the final drive, but Mitchell Trubisky’s hail mary at the end was caught by Kevin White one yard short of the end zone as the Patriots hung on.

Chicago had held a 17-7 lead early in the second quarter, having gone 10-7 up with a remarkable touchdown from Trubisky.

Officially in the books as an eight-yard rush, NFL Stats said the quarterback actually covered just shy of 72 yards as he dropped back, scrambled and circled round before finding a path to the end zone.

The Houston Texans took control of the AFC South with a 20-7 win over the Jacksonville Jaguars, who wound up benching quarterback Blake Bortles following two fumbles.

The win puts Houston clear at the top of the AFC South with the Tennessee Titans having lost a heartbreaker, 20-19, to the Los Angeles Chargers in London.

The Titans had been on the back foot ever since Philip Rivers hit Ty Williams with a 75-yard touchdown pass on Los Angeles’ first offensive play of the game.

But Tennessee rallied in the fourth quarter and Marcus Mariota’s touchdown inside the final minute looked like sending the game to overtime.

Instead coach Mike Vrabel called for a two-point conversion and Andre Phillips batted away Mariota’s pass attempt to give Los Angeles victory.

The defending Super Bowl champions slipped to a fourth defeat of the season as the Carolina Panthers rallied to beat the Philadelphia Eagles 21-17.

Cam Newton threw a one-yard touchdown pass to Greg Olsen with 82 seconds left as Carolina came from 17-0 down for the biggest comeback victory in franchise history.

The Eagles sit second in the NFC East, which is led by the Washington Redskins after they beat divisional rivals the Dallas Cowboys 20-17.

Elsewhere, Kerryon Johnson piled up 158 yards in the Detroit Lions’ 32-21 victory over the Miami Dolphins while the struggling Indianapolis Colts took out their frustrations in a 37-5 rout of the Buffalo Bills.

The Minnesota Vikings picked off New York Jets quarterback Sam Darnold three times on their way to a 37-17 win, while Chandler Catanzaro booted a 59-yard field goal in overtime to give the Tampa Bay Buccaneers a 26-23 win over the Cleveland Browns.