The Dallas Cowboys lost at home for the first time this season as the Tennessee Titans recorded a 28-14 victory at AT&T Stadium.
Quarterback Marcus Mariota threw for two touchdowns and rushed for a third as the Titans snapped a three-game losing streak.
He completed 21 of 29 passes for 240 yards, while his nine-yard touchdown with just over four minutes remaining all but sealed the win.
Tennessee converted 11 of 14 third downs in the match, rallying after a slow start.
The win puts the Titans (4-4) second behind the Houston Texans in the AFC South, while the Cowboys (3-5) are third in the NFC East.