England established complete dominance over a worn and wearied South Africa in Johannesburg, leaving themselves two days to convert their 465-run lead in the fourth Test into a memorable series win.
Captain Joe Root had the rare opportunity to enforce the follow-on for the second match in a row after the hosts were dismissed 217 behind on 183 but opted to hand his seamers a well-earned rest and pile up scoreboard pressure at the Wanderers.
He led the way personally, top-scoring with 58 as his side made 248 all out at a rate of more than four-an-over in their second innings to lay the groundwork for a huge victory at South Africa's 'Bullring'.
Ollie Pope and Buttler had similar ideas but came similar ends, both men aggressively edging to De Kock, who duly became the 18th wicketkeeper to 200 Test dismissals.
Root seemed largely immune to the frenzy but Sam Curran joined in, sprinting to 35 before hooking Hendricks to fine-leg.
Root completed his second fifty of the match, and 48th overall, before he was last man out – Faf Du Plessis taking a staggering one-handed catch to hand Hendricks a five-for on debut.