Amanda Holden has joined the cast of Neighbours in a guest role as the iconic Aussie soap films scenes in London.

As part of the plotline, Holden will play Harriet, sister of Denise van Outen's deceased character Prue and the aunt of Harlow Robinson (Jemma Donovan).

Harlow links up with Aunt Harriet in London as they look to solve "a family mystery" involving Prue, who was blown up by a car bomb last year.

"Like most people in the UK who were around in the late 80's/early 90's, I grew up watching Neighbours every single day of the week," said Holden.

"I was glued to our TV for the wedding of Kylie & Jason (Scott & Charlene) while cursing Mrs Mangle and praying that Mike and Jane would eventually get together! Not to mention all the other greats over the years.

"To now have the opportunity to be a part of such an iconic Australian show is simply fabulous! I can't wait to work with Jemma in London, this feels like a joyous occasion for everyone."

The scenes are being shot this week and will play out on screen next spring.