AFC Wimbledon vs. Morecambe (Saturday, 3.00pm)
AFC Wimbledon will welcome fellow relegation candidates Morecambe to the Cherry Red Records Stadium for their League One battle on Saturday afternoon.
A seven-goal thriller was played out between these two sides in September's reverse fixture, which saw Wimbledon come out on top with a dramatic 94th-minute winner from Ayoub Assal.
We say: AFC Wimbledon 2-2 Morecambe
An entertaining encounter with plenty of goalmouth action is expected on Saturday between two sides who will fancy their chances of securing all three points.
As desperate as Morecambe will be to climb out of the relegation zone and get revenge over Wimbledon, they may have to settle for just a point on this occasion.
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Accrington vs. Sunderland (Saturday, 3.00pm)
In their bid to bounce back to the top of the League One table, Sunderland make the trip to take on Accrington Stanley on Saturday.
The Black Cats suffered a harmful 3-1 defeat at the hands of Lincoln City on Tuesday, while their hosts come into the game on the back of four consecutive matches without a loss.
We say: Accrington Stanley 1-1 Sunderland
With Sunderland frustrated by consecutive games without a victory and hit hard by injuries, we see Saturday's hosts frustrating their visitors and earning a point.
While Stewart will certainly pose an immense threat, Coleman's men are full of confidence and should fancy themselves to avoid a defeat on home turf.
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Bolton vs. Ipswich (Saturday, 3.00pm)
Kieran McKenna will look to continue his winning start to life as Ipswich Town manager on Saturday, when they travel to take on Bolton Wanderers.
Back-to-back wins under the new boss have seen the Tractor Boys climb to 10th spot in the League One table, while their hosts sit 18th, having lost their last four league outings.
We say: Bolton Wanderers 0-2 Ipswich Town
The contrasting form of these two sides should only point towards an away victory for Ipswich on Saturday.
While Evatt's men will be desperate for a result, we see the Tractor Boys' confident and quality-filled squad having enough to leave with all three points.
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Cheltenham vs. Charlton (Saturday, 3.00pm)
Cheltenham Town and Charlton Athletic will do battle on Saturday as both sides look to break concerning winless runs in League One.
After three straight defeats, the visitors sit 14th in the table, while their hosts are just a point better off in 13th spot.
We say: Cheltenham Town 1-2 Charlton Athletic
With both sides equally struggling for confidence and form, this could come down to fine margins, and Charlton possess the core ability to squeeze over the line on Saturday.
Jackson will be hoping for a reaction from his squad, and they should have just enough to make a return to winning ways against a Cheltenham side far from the peak of their powers.
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Crewe vs. Shrewsbury (Saturday, 3.00pm)
Having recently climbed to 22nd spot with a crucial win, Crewe Alexandra will look to further strengthen their position at the bottom end of the League One table on Saturday, when they welcome Shrewsbury Town to Gresty Road.
The hosts moved within four points of safety with a victory over Charlton Athletic on Wednesday, while their visitors come in having won three of their last four league outings.
We say: Crewe Alexandra 1-1 Shrewsbury Town
With two teams relatively high on confidence, we would not be surprised to see either take all three points but ultimately see a share of the spoils as the most likely outcome.
While Crewe have struggled to build consistency on the back of their crucial recent wins, they certainly look revitalised and will be desperate to earn a result on home turf.
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Doncaster vs. Wigan (Saturday, 3.00pm)
Two teams at opposite ends of the League One table will meet on Saturday when bottom-placed Doncaster Rovers host Wigan Athletic at Keepmoat Stadium.
The visitors are enjoying an excellent run of form, having not lost in 14 matches, which is something that they shall be hoping to continue in their next outing.
We say: Doncaster Rovers 0-2 Wigan Athletic
Wigan Athletic will head into this match as the favourites, and they should have more than enough quality to win this particular match.
With the Latics looking for promotion this season, they will not be wanting to drop any points against a team that is sat at the bottom of the league and low in confidence.
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Fleetwood vs. Rotherham (Saturday, 3.00pm)
Two teams at opposing ends of the League One table will meet on Saturday as 19th-placed Fleetwood Town welcome the current league leaders Rotherham United.
The hosts will be hoping to continue on from their recent victory, while the visitors will want to respond to being knocked out of the FA Cup.
We say: Fleetwood Town 1-2 Rotherham United
Fleetwood Town were able to pick up a victory when the two teams met earlier this season, but since then their form has dropped dramatically over the campaign.
Recent performances have improved for the club, but Rotherham United are top of the league, and that added quality should be enough to see them secure another crucial three points towards their potential promotion hopes.
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Gillingham vs. Burton Albion (Saturday, 3.00pm)
Burton Albion shall be hoping to extend their unbeaten run to three games on Saturday when they make the trip to face Gillingham, who are without a win in 13 matches across all competitions.
10 places separate the two teams at the moment, with the hosts currently occupying one of the relegation spots, which they will be keen to escape from.
We say: Gillingham 1-2 Burton Albion
Gillingham have struggled this season, and every game counts for them at the moment due to their position in the league table, adding pressure to this match.
However, Burton Albion have showcased quality on a consistent basis, and that is something that should allow them to pick up all three points.
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Lincoln vs. Cambridge (Saturday, 3.00pm)
Lincoln City are aiming to continue their undefeated start to 2022 on Saturday when they welcome Cambridge United to Sincil Bank.
There is just one point separating the two teams in League One, with the visitors hoping to continue riding their momentum after defeating Newcastle United in the FA Cup.
We say: Lincoln City 1-2 Cambridge United
Both teams are enjoying some great form at the moment, which is something that they will be hoping to continue this weekend, especially against opponents so close to them in the league.
However, after two impressive cup victories, Cambridge United should be able to continue riding that momentum this weekend in order to secure an important win.
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Portsmouth vs. MK Dons (Saturday, 3.00pm)
MK Dons will be keen to maintain their position in the League One playoff spots when they travel to fellow-challengers Portsmouth on Saturday afternoon.
Pompey will begin the weekend outside the playoffs, and are desperate for three points to stop the top six from dragging themselves any further in front.
We say: Portsmouth 1-0 MK Dons
A clash that could shape the playoff positions come the end of the campaign, Portsmouth will be hoping that a victory can cut the gap to those ahead of them.
With the benefit of home support, expect Portsmouth to arrest their recent woes against MK Dons and pick up three points this weekend.
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Sheff Weds vs. Plymouth (Saturday, 3.00pm)
Sheffield Wednesday have a chance to pick up of their first League One victory of 2022 and at the same time close the gap between themselves and Plymouth Argyle, who they will host on Saturday at Hillsborough.
It has been 13 days since the Owls last played a competitive match, losing 1-0 to Shrewsbury earlier this month as they trail the Pilgrims in the table by six points, with Plymouth winning their last three games played in all competitions.
We say: Sheffield Wednesday 2-2 Plymouth Argyle
Having 13 days in between their previous game and this one, we expect Sheffield Wednesday to struggle out of the gate, although playing on their home field should enable them to find their footing eventually, as they have conceded first in their last three league matches played at Hillsborough but avoided defeat each time.
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Wycombe vs. Oxford Utd (Saturday, 3.00pm)
The Wycombe Wanderers head into their League One matchup this weekend with first place on their minds as they welcome Oxford United to Adams Park in Buckinghamshire.
The Blues are unbeaten in their previous three matches and just a point behind Rotherham United and Sunderland for the top spot, while The U's have yet to win a game this year, dropping a 2-0 decision to Lincoln City last weekend.
We say: Wycombe Wanderers 2-1 Oxford United
Wycombe have been the sharper of the two sides thus far in 2022, and while Oxford are still a talented team who should be contending for a promotion, The Chairboys have been a little quicker starting matches and tend to react a little better as well.
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