City could be 17 points adrift of runaway league leaders Liverpool by the time they get underway against the Gunners, while the gap to Leicester City could have grown to nine points following a spell of wild inconsistency by their own standards.
Guardiola's side have enjoyed themselves against Arsenal in recent years, though, and will be favourites to get back to winning ways in the league against a team with only one win from their last 11 outings.
Here, Sports Mole looks at how the visitors could line up for the contest.
Guardiola is still without some key players for this match, and his defensive troubles in particular have been exacerbated by John Stones being ruled out for "a few weeks".
Nicolas Otamendi is the only remaining senior choice to partner Fernandinho at the heart of the defence, then, and there could be a change at left-back too with Benjamin Mendy coming in for Angelino from the team that lost the derby last weekend.
Ederson is fully expected to feature after overcoming a bout of illness during the week, but a bigger question mark hangs over the head of David Silva, who was unable to train on Thursday or Friday due to a leg injury.
Gabriel Jesus scored a hat-trick in that match and will lead the line again in the continued absence of record scorer Sergio Aguero, who could return next weekend.