Just a week ago Mauricio Pochettino's side were still regarded as title contenders, but successive defeats at Burnley and Chelsea have put paid to those hopes and left them looking over their shoulders.
Spurs know that a third straight defeat would leave them just a point above their most hated rivals, and possibly within the reach of fifth place too.
Here, Sports Mole looks at how the hosts could line up for the crunch match at Wembley.
Spurs could be boosted by the return of Jan Vertonghen after he missed the defeat to Chelsea with a hip injury, which could in turn prompt Pochettino to change to a back three.
Erik Lamela is the most likely casualty should that be the case, with Harry Winks and Moussa Sissoko having established themselves as the favoured midfield partnership and Christian Eriksen and Son Heung-min surely undroppable for a game of such magnitude.
Dele Alli is expected to miss this one, though, after Pochettino suggested that the focus was instead on the upcoming games against Borussia Dortmund and Southampton for the midfielder to make his return.
Harry Kane will lead the line once again, meanwhile, having scored eight goals in eight Premier League games against Arsenal.