Leverkusen are currently fifth in the table, level on points with fourth-placed Borussia Monchengladbach, while champions Bayern are seven points clear of second-placed Borussia Dortmund at the summit.
Leverkusen have won three of their four matches since the Bundesliga resumed in the middle of May, including an important 1-0 victory away to Freiburg in their last fixture on May 29.
Peter Bosz's side put seven goals past Werder Bremen and Borussia Monchengladbach in successive matches last month, but they were brought crashing back down to earth at home to Wolfsburg on May 26, suffering a 4-1 reverse as their seven-game unbeaten run ended in surprise fashion.
Leverkusen, as mentioned, are level on points with the side directly above them, while they sit just two points off third-placed RB Leipzig and four behind second-placed Dortmund.
It is incredibly difficult to imagine a scenario where Die Werkself challenge for the title, but a victory over Bayern this weekend would give them real hope in the fight for second position.
There will once again be eyes on Kai Havertz this weekend, with the 20-year-old scoring six times in his last four Bundesliga appearances, and it has been suggested that Bayern could hold talks with Leverkusen ahead of the match over a potential summer deal.
Bayern's form since the restart has been perfect, picking up four wins from four matches, including a key 1-0 victory over Dortmund on May 26 to open up a healthy lead at the summit.
Union Berlin, Eintracht Frankfurt and Fortuna Dusseldorf have also been beaten by the champions since the middle of May, and another victory on Saturday would see them take a huge step towards retaining the title.
Hansi Flick's side have actually now won their last eight Bundesliga matches, while they are unbeaten in Germany's top flight since the start of December, which is an indication of the size of the task facing Leverkusen at the BayArena in the latest round of fixtures.
The German champions are comfortable at the summit, although they will face a tough game against Borussia Monchengladbach next weekend, and a poor result this weekend might well give Dortmund & Co. confidence.
Leverkusen actually ran out 2-1 winners when the two sides locked horns at the Allianz Arena earlier this season, while they also recorded a 3-1 victory over Bayern in the corresponding game last term.
Leverkusen Bundesliga form: DWWWLW
Leverkusen form (all competitions): WWWWLW
Bayern Bundesliga form: WWWWWW
Bayern form (all competitions): WWWWWW
Havertz was forced off during Leverkusen's clash with Freiburg last time out, but the Germany international has been declared fit for Saturday's contest in what is a huge boost for the home side.
The youngster is again expected to lead the line despite Kevin Volland and Lucas Alario returning to fitness, and Leverkusen's squad is in good shape at the moment with Lars Bender their only confirmed absentee.
Bosz has plenty of decisions to make with Moussa Diaby, Kerem Demirbay and Karim Bellarabi all named on the bench against Freiburg, meaning that there were starts for the likes of Leon Bailey and Nadiem Amiri.
Diaby, Demirbag and Bellarabi are all pushing to return to the XI against Bayern, though, while there should be a spot in defence for Edmond Tapsoba, who was also left out of the starting team for the Freiburg fixture.
Leverkusen possible starting lineup:
Hradecky; Weiser, S. Bender, Tapsoba, Sinkgraven; Aranguiz, Demirbay; Bellarabi, Amiri, Diaby; Havertz
Bayern possible starting lineup:
Neuer; Pavard, Boateng, Alaba, Davies; Kimmich, Thiago; Gnabry, Muller, Coman; Lewandowski
We say: Leverkusen 1-2 Bayern
Leverkusen have won two and lost just one of their last six home matches against Bayern, who have also lost the last two fixtures between the two sides. There is no question that Bosz's side are capable of picking up a victory, but we just fancy the champions to have enough to pick up another vital three points.