Borussia Dortund manager Jurgen Klopp has named a strong starting XI as his side attempt to close the gap on the top three.
For the home side, Robert Lewandowski, Mario Gotze and Marco Reus all start in an attacking lineup against ninth-placed Stuttgart.
The visitors have Vedad Ibisevic as the lone striker, with midfield support from Martin Harnik and Raphael Holzhauser.
Dortmund: Weidenfeller; Subotic, Hummels, Schmelzer, Piszczek; Kehl, Gundogan; Reus, Grosskreutz, Gotze; Lewandowski
Stuttgart: Ulreich; Neidermeier, Boka, Tasci, Sakai; Kvist, Traore, Harnik, Gentner, Holzhauser; Ibisevic