West Ham vs. Leeds (Sunday, 1.30pm)
Revelling in one of their most famous European nights in history, West Ham United return to domestic duties to host Leeds United at the London Stadium in Sunday's Premier League affair.
While David Moyes's side were busy booking their tickets to the Europa Conference League final, the Whites have had a week to reflect on their enthralling 2-2 draw versus Newcastle United.
We say: West Ham United 1-2 Leeds United
With Leeds both scoring and conceding in their last 11 Premier League matches, goals are virtually guaranteed whenever the Whites step foot onto the field, and they have shown enough under Allardyce so far to suggest that they can trouble a weary West Ham side.
As well as jellied legs, Moyes's men may already have one eye on the Europa Conference League final with safety almost assured, and we would not be surprised to see Leeds capitalise on West Ham's continental exertions to pinch a priceless victory in their battle against demotion.
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Brighton vs. Southampton (Sunday, 2.00pm)
In their first Premier League game since their relegation to the Championship was confirmed, Southampton face a taxing trip across the South coast to meet Brighton & Hove Albion on Sunday afternoon.
The Saints' fate was sealed in a 2-0 defeat to Fulham last weekend, while Roberto De Zerbi's men were brought crashing back down to earth in a 4-1 midweek humbling against Newcastle United.
We say: Brighton & Hove Albion 3-1 Southampton
Strange things can happen when a side have already been condemned to the drop, and given Brighton's recent shortcomings against bottom-half teams, Southampton should be given free rein to attack a fatigued Seagulls backline this weekend.
Such a gung-ho approach will no doubt have its drawbacks, though, and with several key players expected to return to the first XI, Brighton should once again follow a chastening defeat with a dominant win - the first for the home side in 12 attempts in this fixture - to get their Europa League charge back in track.
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Man City vs. Chelsea (Sunday, 4.00pm)
Manchester City welcome Chelsea to the Etihad Stadium on Sunday knowing that a victory will be enough to see them crowned champions of the Premier League for a third successive season.
The West Londoners are seeking revenge having already lost three times against the Citizens this campaign, including a 1-0 league defeat at Stamford Bridge in January courtesy of a second-half strike from Riyad Mahrez.
We say: Manchester City 3-0 Chelsea
Even if Guardiola decides to rotate his side, Man City have the strength in depth to dispatch a Chelsea outfit merely playing for pride and experiencing an experimental phase as the season draws to a close.
The Citizens have won their final home league fixture in eight of the last nine seasons and we expect them to secure another comfortable victory over the Blues in front of a party atmosphere at the Etihad.
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> How Chelsea could line up against Man City
> How Man City could line up against Chelsea
