Libertad vs. U. Catolica (Wednesday, 11.00pm)
With the Copa America now done and dusted, the Copa Sudamericana will recommence in midweek, with Club Libertad taking on Universidad Catolica at Estadio ueno Defensores del Chaco.
The round of 32 will feature the third-placed teams from the Copa Libertadores groups taking on the teams that finished second in the group stage of this competition for a spot in the last 16.
We say: Club Libertad 2-1 Universidad Catolica
Barring their Copa Libertadores disappointment, Libertad are enjoying a very impressive season and were in excellent form ahead of the international break. The hosts also got the better of this opponent a couple of seasons ago and we feel they will do likewise this time around.
> Click here to read our full preview for this match
Barcelona vs. Bragantino (Thursday, 1.30am)
Bragantino will make the trip to Estadio Monumental Banco Pichincha to face Barcelona SC in the first leg of their Copa Sudamericana round of 32 tie on Thursday morning.
These two will lock horns again next week in Sao Paulo, and the winner of the two-legged tie will earn a spot in the last 16, where they will be up against Corinthians.
We say: Barcelona SC 1-1 Bragantino
While Barcelona's record against Brazilian opponents is not the greatest, they are set to face a Bragantino side that are some way from their best at the moment.
The hosts will know that getting a positive result will be crucial here before heading to Sao Paulo next week, and we feel they will be able to keep the tie in the balance with a draw in this one.
> Click here to read our full preview for this match
Independiente vs. Boca Juniors (Thursday, 1.30am)
One of the picks of the Copa Sudamericana round-of-32 ties sees Independiente del Valle taking on Boca Juniors, with the first leg set to get underway on Thursday morning.
Estadio Banco Guayaquil will host the first leg of this encounter before we head to La Bombonera next week, and the winner across the two matches will move on to face Cruzeiro in the round of 16.
We say: Independiente del Valle 1-1 Boca Juniors
While the hosts enter this match with the better form line, they have not played in almost two months and may just need this match to find top gear.
Boca Juniors, while not at their best domestically this season, have turned up in this competition and we feel they will keep the tie level, giving them something to take back to Buenos Aires next week.