On-loan Doncaster Rovers left-back Yun Suk-Young has been ruled out for six weeks after rolling his ankle in training last week.
The South Korean, who is on loan from Queens Park Rangers until the end of December, adds to a growing list of problems in defence for Donny manager Paul Dickov, with James Husband, Rob Jones and Jamie McCombe also sidelined.
"It feels like there's a little bit of a curse going on at the moment," said Dickov.
Manchester City loanee Reece Wabara is likely to fill in on the left of defence.
Next up for the South Yorkshire club in the Championship is a home match against the division's bottom club, Yeovil Town, with whom they were promoted from League One last season.