N. Ireland vs. Italy (Monday, 7.45pm)
Italy's chance to banish their demons from failing to qualify for Russia 2018 comes down to the wire on Monday night, as they visit Northern Ireland in a decisive World Cup Qualifying game.
While the European champions could assure progress to next year's finals with a win, their hosts will be playing only for pride and the opportunity to finish third in Group C.
We say: Northern Ireland 0-2 Italy
Playing pressure-free, and with all their main men at their disposal, Northern Ireland can pose some problems for an Italian side which must conquer not only their opponents but also the occasion.
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> How Italy could line up against Northern Ireland
Switzerland vs. Bulgaria (Monday, 7.45pm)
After escaping with a point from Rome in their most recent World Cup Qualifying fixture, Switzerland welcome already eliminated Bulgaria to Lucerne on Monday, seeking a win which could earn them a ticket to Qatar.
While the Swiss must better Italy's result - or match them and improve their goal difference by three - to top Group C and progress to the finals automatically, their Balkan counterparts are playing only for pride and the chance to finish third in the standings.
We say: Switzerland 2-0 Bulgaria
Strong favourites Switzerland should take care of business in Lucerne, but will still rely on Northern Ireland to do them a favour in the other high-stakes Group C clash - the result of which could decide their destiny.
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Austria vs. Moldova (Monday, 7.45pm)
Austria will be looking to round off their World Cup 2022 qualification campaign on a positive note when they welcome Group F strugglers Moldova on Monday night.
The home side are currently fourth in the section, having picked up 13 points from nine matches, while Moldova are bottom with just a single point to show from their nine games thus far.
We say: Austria 2-0 Moldova
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Israel vs. Faroe Islands (Monday, 7.45pm)
Israel will be looking to round off their World Cup 2022 qualification campaign on a positive note when they welcome Faroe Islands for their final Group F contest on Monday.
The home team are third in the section, seven points behind second-placed Scotland, while Faroe Islands are fifth, three points clear of sixth-placed Moldova with one game left.
We say: Israel 2-0 Faroe Islands
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Scotland vs. Denmark (Monday, 7.45pm)
Fresh from securing second position in Group F and a spot in the World Cup 2022 qualification playoffs, Scotland will welcome runaway section leaders Denmark to Glasgow on Monday night.
Friday's 2-0 victory in Moldova was enough to guarantee second in the group, while Denmark made it nine straight wins in the section with a 3-1 success over Faroe Islands on the same night.
We say: Scotland 1-1 Denmark
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Albania vs. Andorra (Monday, 7.45pm)
A World Cup 2022 qualifying dead rubber will take place in Group I on Monday, as two eliminated sides in Albania and Andorra will go head-to-head on the final matchday.
The visitors cannot finish any higher or lower than fifth, while Edoardo Reja's men will seek the consolation prize of a third-placed ranking.
We say: Albania 1-0 Andorra
One would typically back Albania to get the job done in relatively routine fashion with a fully-fit squad, but it should be anything but a walkover on Monday, with Reja's men both low on numbers and confidence.
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Poland vs. Hungary (Monday, 7.45pm)
Surely consigned to a second-placed finish in World Cup 2022 Qualifying Group I, Poland welcome Hungary to Warsaw for their final game of the group on Monday.
The hosts sit three points behind England heading into the final matchday, while Marco Rossi's men are simply playing for pride this week.
We say: Poland 3-1 Hungary
Poland will be aware that their chances of pipping England to top spot are virtually non-existent on Monday, but Sousa's Lewandowski-inspired side can keep their strong streak against Hungary going with a goal-laden showing.
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San Marino vs. England (Monday, 7.45pm)
With only one point needed to book their plane tickets to Qatar, England face off against San Marino in their final World Cup 2022 qualifying battle on Monday.
The Three Lions are three points clear at the top of the Group I rankings with one game remaining, while their hosts will be glad to see the back of another doomed campaign.
We say: San Marino 0-6 England
No matter what XI Southgate sends onto the field on Monday, a comprehensive thrashing is the only outcome on the menu, with Albania feeling the full force of the Three Lions' rampant attacking machine on Friday.
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> How England could line up against San Marino body check tags ::