Everton's 2020-21 season begins with a trip to North London to face Tottenham Hotspur, before welcoming newly-promoted West Bromwich Albion to Goodison Park for their first home game of the campaign.
The Merseyside derby at home to Liverpool stands out in their fifth match as they look to end a long winless record against their near neighbours, with the return fixture against the champions coming in February.
It promises to be a difficult festive period - every match in December comes against teams that finished above them last season, including three home games in a row which see them welcome Chelsea, Arsenal and Manchester City to Merseyside.
Man City are also the opponents on the final day as Everton conclude their campaign with a trip to the Etihad Stadium.
SEPTEMBER
12: Tottenham Hotspur (a)
19: West Brom (h)
26: Crystal Palace (a)
OCTOBER
3: Brighton (h)
17: Liverpool (h)
24: Southampton (a)
31: Newcastle United (a)
NOVEMBER
7: Manchester United (h)
21: Fulham (a)
28: Leeds United (h)
DECEMBER
5: Burnley (a)
12: Chelsea (h)
15: Leicester City (a)
19: Arsenal (h)
26: Sheffield United (a)
28: Manchester City (h)
JANUARY
2: West Ham (h)
12: Wolves (a)
16: Aston Villa (a)
26: Leicester City (h)
30: Newcastle United (h)
FEBRUARY
2: Leeds (a)
6: Manchester United (a)
13: Fulham (h)
20: Liverpool (a)
27: Southampton (h)
MARCH
6: Chelsea (a)
13: Burnley (h)
20: West Brom (a)
APRIL
3: Crystal Palace (h)
10: Brighton (a)
17: Tottenham (h)
24: Arsenal (a)
MAY
1: Aston Villa (h)
8: West Ham (a)
11: Sheffield United (h)
15: Wolves (h)
23: Manchester City (a)
