Dusseldorf drew their fourth game in succession against FC Koln last time out, while Schalke suffered a dismal 3-0 home defeat to Augsburg at the weekend.
Even though Dusseldorf are the only Bundesliga club outside of the top four without a defeat in their last five fixtures, Uwe Rosler's side are still at real risk of a return to Germany's second division should results not improve.
Dusseldorf are enjoying their second consecutive season in the German top flight since taking the 2017-18 2. Bundesliga title, but they currently find themselves in the relegation playoff spot after 27 games.
The 16th-placed side looked to be on course to record their first victory since February against Koln on Sunday, but the home side staged a late comeback to salvage a 2-2 draw and leave Rosler frustrated.
Dusseldorf's fourth draw on the bounce leaves them on 24 points at this stage of the campaign, and Rosler will be determined to see his team pick up their first three points on home soil since December against a depleted Schalke side.
Nevertheless, Dusseldorf are within touching distance of Mainz 05 following their 5-0 thrashing at the hands of RB Leipzig, and a victory for Rosler's men could temporarily lift them to safety should Mainz lose to Union Berlin.
Meanwhile, Schalke are a side in turmoil following two crushing defeats since the Bundesliga resumed amid the coronavirus pandemic.
David Wagner was forced to witness his side be dominated by a struggling Augsburg at the weekend as the away side ended a four-game losing run with relative ease at the Veltins-Arena.
Thankfully for Wagner, Schalke's strong early-season form sees them sit comfortably in eighth, but their European hopes seem to be dwindling by the week after a succession of poor results.
Indeed, Schalke have lost five of their last six outings in all competitions and have not tasted success in the Bundesliga since their 2-0 victory over Borussia Monchengladbach in January.
Schalke's away form is even more cause for concern; Wagner's men have failed to score in their last five games on the road in Germany's top flight, conceding 12 goals in the process.
Dusseldorf Bundesliga form: LWDDDD
Dusseldorf form (all competitions): WDLDDD
Schalke 04 Bundesliga form: DLLDLL
Both managers will be expected to make changes to combat the hectic Bundesliga schedule.
Midfielder Suat Serdar limped off on Sunday and is unlikely to feature in midweek.
Dusseldorf possible starting lineup:
Kastenmeier; Zimmermann, Ayhan, Hoffmann, Giesselmann; Bodzek, Tommy, Morales; Skrzybski, Hennings, Fink
Schalke 04 possible starting lineup:
Schubert; Kenny, Sane, Kabak, Oczipka; Mascarell, McKennie; Caligiuri, Schopf, Matondo; Raman
We say: Dusseldorf 1-1 Schalke 04
Both sides are in a desperate situation and are vying to get their Bundesliga campaigns back on track, but we think that a draw is the most likely result between two clubs seriously lacking confidence at this stage of the season.