Finland vs. Kazakhstan (Saturday, 2.00pm)
Finland and Kazakhstan square off in Helsinki on Saturday afternoon with both nations still searching for their first win during World Cup qualifying.
However, the home side have played less games than their rivals, leaving them aware that victory at the weekend will put them in a strong position to finish in second place in Group D.
We say: Finland 2-1 Kazakhstan
At some point during this campaign, the remarkable run of draws will come to an end. We feel that could occur on Saturday afternoon with a fresher Finland squad potentially outlasting their opponents.
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Cyprus vs. Russia (Saturday, 5.00pm)
Russia continue their quest for a place at Qatar 2022 on Saturday, as they travel to meet a Cyprus side still reeling from a humbling midweek defeat.
The pair convene in Nicosia, with the visitors three points clear of their Mediterranean counterparts after the first four games, and tied at the top of a congested Group H table.
We say: Cyprus 0-1 Russia
Cyprus tend to fare better on home soil - remaining unbeaten against Slovakia and Slovenia in Nicosia earlier in the process - but are set to be edged out by a capable Russia side on Saturday evening.
The visitors can push Croatia all the way for top spot in the group, and their greater top-level experience will see them to three points in the Mediterranean.
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Rep. Ireland vs. Azerbaijan (Saturday, 5.00pm)
Following their cruel loss at the hands of Portugal, Republic of Ireland are still seeking their World Cup qualifying victory heading into Saturday's visit of Azerbaijan.
The Boys in Green are fourth in Group A after three matches and are only kept off bottom spot by next opponents Azerbaijan, who are also without a point thus far.
We say: Republic of Ireland 1-0 Azerbaijan
Ireland are on their worst ever run of competitive games without a victory and will be desperate to bring an end to that unwanted record at the 15th attempt.
The Boys in Green came within minutes of beating Portugal last time out, though, and we can see them finally getting points on the board against fellow out-of-form side Azerbaijan.
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Serbia vs. Luxembourg (Saturday, 5.00pm)
Serbia and Luxembourg meet in Belgrade on Saturday evening in a game which will play a significant part in deciding who finishes in the top two of Group A.
While the home side are aware that they will be on the brink of achieving that target with victory at the weekend, Luxembourg will overtake them if they record yet another shock win in World Cup qualifying.
We say: Serbia 3-0 Luxembourg
While Luxembourg deserve plenty of respect ahead of this game, we cannot ignore that this is one of the biggest matches in their history. With that in mind, it is conceivable to believe that the extra pressure may play into the hands of their talented hosts.
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Latvia vs. Norway (Saturday, 5.00pm)
Following a hard-earned point in midweek, Norway travel to Latvia in search of a win to boost their hopes of qualifying for Qatar 2022.
While Stale Solbakken's side held the Netherlands to a draw, their opponents this Saturday took care of business against World Cup Qualifying Group G minnows Gibraltar.
We say: Latvia 1-3 Norway
Norway's new generation have an abundance of talent in the final third, with several players capable of causing Latvia headaches - even if Solbakken decides to rotate his resources.
Their forward options - allied to a solid base, which largely kept the Netherlands at bay - are set to secure all three points, before finishing off a successful spell with another win at home to Gibraltar.
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Slovenia vs. Malta (Saturday, 5.00pm)
Following one of their best results of recent times, Malta visit Slovenia on Saturday, as they seek another unlikely win in Group H of European World Cup Qualifying.
While the visitors are ranked 177th in the world at present, their hosts are expected to be among the contenders for a top-two place at the end of the process - but have some catching-up to do.
We say: Slovenia 2-0 Malta
Though their visitors are on a high from a fine midweek win, Slovenia are tough opponents to get past at the back and are motivated by the need of maximum points to stay in the race for Qatar.
Experienced campaigners such as Sporar and Ilicic will have the nous to take care of business in the final third too, so Matjaz Kek's men are bound for victory ahead of the daunting trip to Croatia.
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Ukraine vs. France (Saturday, 7.45pm)
The top two teams in World Cup 2022 qualification Group D prepare for battle in Kiev on Saturday night, as Ukraine welcome France to the NSK Olimpiyskiy on matchday five for both nations.
Oleksandr Petrakov's resident draw specialists played out a thrilling 2-2 stalemate with Kazakhstan last time out, while France could only take a point from their clash with Bosnia-Herzegovina.
We say: Ukraine 0-1 France
Ukraine are no pushovers, and their resilient nature has been there for all to see since qualifying kicked off, but four games without a win does spell concern for new manager Petrakov.
France's winless run may also lead to some apprehension creeping in for the visiting camp, but we are still confident in Les Bleus' ability to grind out a narrow but vital win to extend their lead at the top.
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> How France could line up against Ukraine
Faroe Islands vs. Denmark (Saturday, 7.45pm)
Denmark will be looking to maintain their 100% start to World Cup qualifying when they travel to the Faroe Islands on Saturday evening.
The Danes are one of only three European nations yet to concede during their qualification campaign so far, while the hosts have let in 12 goals already in their first four matches.
We say: Faroe Islands 0-3 Denmark
Everything points towards a comfortable victory for Denmark, who should have no problems in maintaining their perfect record in qualifying.
The Danes are yet to concede a goal so far in Group F and we can see them keeping another clean sheet on the road against the Faroe Islands.
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Israel vs. Austria (Saturday, 7.45pm)
Austria continue their pursuit of a place at Qatar 2022 on Saturday, as they visit Israel in the second match of their World Cup qualifying triple-header.
The pair are direct rivals for a probable playoff place; locked together on seven points apiece in the Group F table - five points adrift of leaders Denmark.
We say: Israel 1-2 Austria
Though Israel's forward line is sure to present Austria with some serious challenges - particularly on home soil - the visitors possess a great understanding forged through the past few years.
Alaba and Arnautovic bring a cutting edge that will be hard for the home side to match too, so the Austrians are set to go clear of their counterparts in the race for a top-two place.
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Scotland vs. Moldova (Saturday, 7.45pm)
Scotland will be looking to bounce back from their midweek defeat against Denmark with a victory, when they host Moldova for the fifth match of their World Cup Qualifying campaign in Group F.
Meanwhile, the visitors – ranked 175th in the FIFA world rankings – are searching for their first competitive win in 17 matches.
We say: Scotland 2-0 Moldova
With the return of a few key players to the squad, Clarke will be confident that his Scotland side have enough quality to secure all three points on Saturday.
We are predicting the hosts will claim a routine victory at Hampden Park, as the visitors are unlikely to cause too many problems in the final third.
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Gibraltar vs. Turkey (Saturday, 7.45pm)
Top and bottom meet in World Cup qualifying Group G on Saturday evening as Turkey travel to Gibraltar in the fifth round of matches.
Turkey have won two and drawn two of their opening four games, while Gibraltar are without a win as we approach the midway point on the road to Qatar 2022.
We say: Gibraltar 0-2 Turkey
Turkey are winless in five competitive matches since kicking off their World Cup qualifying campaign with back-to-back victories.
Minnows Gibraltar are the perfect next opponents for the Crescent-Stars, however, and we can see them kickstarting their campaign with a morale-boosting win on Saturday.
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Netherlands vs. Montenegro (Saturday, 7.45pm)
The Netherlands and Montenegro will face each other for the very first time when they do battle at the Philips Stadion for the fifth match of their World Cup Qualifying campaign in Group G.
Both nations have identical records from their first four games, claiming seven points, with the hosts only sitting above the visitors on goal difference.
We say: Netherlands 2-0 Montenegro
With Turkey expected to beat Gibraltar on Saturday, a win for the Netherlands or Montenegro is unlikely to see them climb to the summit of Group G.
However, three points secured for either side at the Philips Stadion would put them in a stronger position to finish in one of the top two qualification places.
The hosts will be the favourites to come out on top this weekend and we cannot see them having too many problems on home soil.
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> How the Netherlands could line up against Montenegro
Slovakia vs. Croatia (Saturday, 7.45pm)
Slovakia and Croatia continue their World Cup qualifying campaign on Saturday evening in a group where top and bottom are separated by just three points.
While Croatia could move clear at the top of Group H with victory at the weekend, defeat in Bratislava wold put them at risk of dropping into the mid-table positions.
We say: Slovakia 1-2 Croatia
Croatia have performed well below their best during this campaign, and we do not expect much different on Saturday. Nevertheless, their extra big-game experience could prove pivotal, leading us to predict a narrow win for the visitors.