Giorgos Karagounis and Simon Davies will not be offered new deals at Craven Cottage this summer, manager Martin Jol has said.
Karagounis, 36, joined the Cottagers on a free transfer in September and has been popular with the Fulham faithful.
Despite this, the Greek will not be considered for a fresh contract.
"It is most likely that Sunday will be the last game that Giorgos will play for Fulham," said Jol.
"He's had a terrific year and the Premier league was a great experience. There would be options for him to stay in England and would consider any challenges that may be available.
"It's very good that the fans of Fulham have recognised his contributions this season to vote him as the second best player and he will always have them in his heart."
Davies, 33, will move on after six seasons in West London which have seen him play over 150 games.
"The thing with Simon is as long as I was here he was never fully fit for more than two or three weeks, and that's a problem," said Jol.
"When he was fit he was a wonderful player but if he's not fit we've got a problem, so we've got to sit down with him and talk about it."
The club are said to have already moved for new midfielders and, according to reports, they are expected to confirm the signing of Ghana international Derek Boateng on a free transfer.
