Alvaro Cervera's side will enter the match off the back of a 1-0 success at Athletic Bilbao, while Granada lost 6-1 at Atletico Madrid in their last league game on September 27.
Cadiz finished second in last season's Segunda Division to secure a return to this level of football for the first time since being relegated at the end of the 2005-06 campaign.
The newly-promoted side opened their season with a 2-0 home defeat to Osasuna but put three points on the board eight days later by beating Huesca 2-0 on the road.
Another defeat followed at home to Sevilla last weekend, but Alvaro's side will enter this match off the back of an excellent 1-0 victory at Athletic on Thursday, which was decided by an own goal from Unai Lopez.
Cadiz have been busy during this summer's transfer window, signing the likes of Alvaro Gimenez, Choco Lozano and Ivan Alejo, while experienced striker Alvaro Negredo has also joined the club on a free transfer.
Granada, meanwhile, have had an incredibly busy start to the season due to their involvement in the qualifying rounds of the Europa League.
Diego Martinez's side finished seventh in Spain's top flight last term, which proved to be their highest placing at this level of football since 1973-74, and they have managed to progress to the group stage of the Europa League.
Indeed, victories over Teuta Durres and Lokomotivi Tbilisi in the qualifying rounds were followed by a 3-1 success at Malmo in the playoffs on Thursday night, ensuring that they would qualify for the main tournament.
Granada have also made a solid start to their league season, picking up six points from an unavailable nine by beating Athletic and Alaves in their opening two matches.
Cadiz La Liga form: LWLW
Granada La Liga form: WWL
Granada form (all competitions): WWWWLW
Marcos Lopez could come into the side as a replacement for Akapo, but there are not expected to be too many other changes from the side that impressively won at San Mames with nine men.
Cadiz possible starting lineup:
Ledesma; Lopez, Jimenez, Cala, Espino; Carcelen, Fernandez, Jonsson, Malbasic; Alex; Lozano
Granada possible starting lineup:
Silva; Diaz, Duarte, Sanchez, Neva; Puertas, Montoro, Gonalons, Herrera, Machis; Soldado
We say: Cadiz 1-2 Granada
Cadiz have impressed with their performances in the early weeks of the campaign, but Granada have proved themselves to be a very, very good side. Thursday's clash with Malmo would have consumed a lot of energy, but the result was excellent, and we fancy the visitors to pick up another victory in this match.