Ipswich vs. Wycombe (Wednesday, 7.45pm)
Ipswich Town will welcome Wycombe Wanderers to Portman Road on Wednesday with the hosts aiming to end a six-game winless run in all competitions.
Meanwhile, the visitors enter the fixture in fifth place in League One, and they will be looking to extend their current unbeaten run to six matches.
We say: Ipswich Town 2-1 Wycombe Wanderers
Ipswich won the reverse fixture by a comfortable 4-1 scoreline, and though Wednesday's contest should be closer, we think the hosts will benefit from the new manager bounce to edge out Wycombe at Portman Road.
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MK Dons vs. Cheltenham (Wednesday, 7.45pm)
MK Dons will aim to collect consecutive victories, when they welcome Cheltenham Town to Stadium MK on Wednesday.
Meanwhile, the visitors enter the contest in 14th position, and they are looking to halt their current poor run of form that has seen them fail to win in their last five League One games.
We say: MK Dons 2-0 Cheltenham Town
Having lost once in their last five games in all competitions, MK Dons will be confident of collecting all three points on Wednesday, and we think they will profit against a Cheltenham side that are currently in a poor run of form.
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Morecambe vs. Crewe (Wednesday, 7.45pm)
Morecambe will welcome Crewe Alexandra to the Mazuma Stadium in a battle at the bottom of the League One table.
Both sides currently occupy a position in the relegation zone, with Crewe rooted to the foot of the division and Morecambe sitting two points from safety.
We say: Morecambe 2-0 Crewe Alexandra
Neither side can afford any more slip-ups if they wish to retain their position in the league, especially Crewe whose future looks bleak heading into 2022.
With the backing of home support, we expect Morecambe to just about edge this one.
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Oxford Utd vs. AFC Wimbledon (Wednesday, 7.45pm)
Playoff chasing Oxford United will continue their push for promotion when they host relegation-threatened AFC Wimbledon at the Kassam Stadium on Wednesday evening.
Oxford occupies the final League One playoff position heading into the mid-week action, whilst Wimbledon are hovering dangerously above the relegation zone.
We say: Oxford United 2-1 AFC Wimbledon
Two sides with contrasting fortunes so far this season, the form book points towards a comfortable Oxford win.
Whilst Wimbledon will likely be no pushovers, the playoff chasing U's should have enough to edge past their London opponents.
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Plymouth vs. Portsmouth (Wednesday, 7.45pm)
Both playoff hopefuls Plymouth Argyle and Portsmouth will be keen to pick up points when the pair meet on Wednesday afternoon.
The hosts will begin the week inside the top six, whilst Portsmouth travel to Devon looking to cut the gap between themselves and the playoffs.
We say: Plymouth Argyle 1-1 Portsmouth
A tight battle at the top of League One, with its result likely to have huge implications on the race for a playoff spot.
Portsmouth have enjoyed the upper-hand over Argyle of late, but it is likely this one will end in a stalemate.
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Rotherham vs. Lincoln (Wednesday, 7.45pm)
League One leaders Rotherham United will continue their pursuit of an immediate return to the Championship when they welcome Lincoln City to the New York Stadium on Wednesday evening.
Just the one point separates Rotherham to second-placed Sunderland as the title race begins to hot up in League One.
We say: Rotherham United 2-0 Lincoln City
Defeats have been a rarity for Rotherham this season, meaning the Boxing Day loss would have no doubt hurt the Millers dressing room.
Expect them to bounce back, and strongly, against a struggling Lincoln outfit.
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Shrewsbury vs. Accrington (Wednesday, 7.45pm)
Both Shrewsbury Town and Accrington Stanley will be looking to make it three League One victories in a row when they lock horns in Shropshire on Wednesday night.
Shrewsbury will enter the clash off the back of a 3-0 win at Fleetwood Town on Boxing Day, while Accrington recorded a 1-0 victory over Rotherham United on the same afternoon.
We say: Shrewsbury Town 1-1 Accrington Stanley
Both sides will enter this match in good confidence and will fancy their chances of putting another three points on the board; we are expecting it to be a tight affair, though, and have had to settle on a score draw.
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Wigan vs. Fleetwood (Wednesday, 7.45pm)
Wigan Athletic will be looking to stretch their unbeaten run of form in League One to eight matches when they welcome Fleetwood Town to the DW Stadium on Wednesday night.
The home side have not been in action since overcoming Oxford United on December 18, but Fleetwood played on Boxing Day, suffering a 3-0 defeat to Shrewsbury Town in Lancashire.
We say: Wigan Athletic 2-0 Fleetwood Town
The state of Wigan's squad heading into this match is unclear, but the club are confident that the match will go ahead, and we are expecting them to have too much quality for Fleetwood, who are now hovering dangerously close to the relegation zone heading towards 2022.
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