The Foxes beat Brighton & Hove Albion last weekend and have had an eight-day rest ahead of this clash with United, who are rumoured to be on the verge of parting company with boss Chris Wilder.
Here, Sports Mole rounds up all of the latest team news for the two clubs.
Sports Mole's predicted XI: Schmeichel; Amartey, Fofana, Soyuncu; Pereira, Tielemans, Ndidi, Tavares, Castagne; Vardy, Iheanacho
Sports Mole's predicted XI: Ramsdale; Jagielka, Ampadu, Bryan; Baldock, Lundstram, Norwood, Fleck, Stevens; McGoldrick, Sharp
Watch the Sports Mole Football Shorts prediction for this game below: