SM
| Venue: Old Trafford |
Manchester United | ||
| G | 1 | David De Gea |
| CD-L | 2 | Victor Lindelöf |
| CD-R | 12 | Chris Smalling |
| LB | 23 | Luke Shaw |
| RB | 18 | Ashley Young |
| M | 9 | Romelu Lukaku |
| CM | 39 | Scott McTominay |
| AM | 7 | Alexis Sánchez S  |
| LM | 6 | Paul Pogba |
| RM | 15 | Andreas Pereira S |
| CF-R | 10 | Marcus Rashford S |
| Sub | 20 | Diogo Dalot |
| Sub | 17 | Fred |
| Sub | 44 | Tahith Chong |
| Sub | 16 | Marcos Rojo |
| Sub | 13 | Lee Grant |
| Sub | 3 | Eric Bailly |
| Sub | 47 | Angel Gomes |
Southampton | ||
| G | 28 | Angus Gunn |
| CD | 3 | Maya Yoshida S |
| CD-L | 4 | Jannik Vestergaard |
| CD-R | 35 | Jan Bednarek |
| CM-L | 23 | Pierre-Emile Højbjerg |
| CM-R | 16 | James Ward-Prowse |
| AM | 14 | Oriol Romeu |
| LM | 21 | Ryan Bertrand |
| RM | 43 | Yann Valery |
| CF-L | 10 | Charlie Austin S |
| CF-R | 22 | Nathan Redmond |
| Sub | 15 | Sam Gallagher |
| Sub | 17 | Stuart Armstrong |
| Sub | 1 | Alex McCarthy |
| Sub | 5 | Jack Stephens |
| Sub | 11 | Mohammed Elyounoussi |
| Sub | 33 | Matt Targett |
| Sub | 55 | Callum Slattery |
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