Jurgen Klopp's side fell to their first league loss of the season at the hands of Manchester City in their most recent top-flight game and were then eliminated in the third round of the FA Cup by Wolverhampton Wanderers.
The Reds still enjoy a four-point lead at the top of the table but will know that a third consecutive defeat would open the door for Manchester City to really put the pressure on in the title race.
Here, Sports Mole looks at how Liverpool could line up against the Seagulls.
Liverpool are facing a centre-back shortage after Dejan Lovren was forced off in the opening stages of the FA Cup defeat to Wolves, and Klopp is unlikely to throw 16-year-old Ki-Jana Hoever into a Premier League game despite his mature performance in that match.
Fabinho is therefore expected to continue as a makeshift centre-back, with Joe Gomez and Joel Matip also still sidelined.
Reds fans will breathe a sigh of relief that Virgil van Dijk has shaken off his own knock and will start - one of a host of first-team players set to come back into the team for this one.
Jordan Henderson is expected to overcome a knock he suffered against Man City, while further forward Xherdan Shaqiri could be one of few players to keep his place from Monday night.