Chris Basham was the latest to pull up in last weekend's defeat to Fulham, and he will miss up to four weeks to join fellow defenders Jack O'Connell, John Egan and former Liverpool man Jack Robinson on the sidelines.
Omar Bogle was also injured in that damaging loss at Craven Cottage, picking up a leg injury during a challenge from Alphonse Areola which Chris Wilder felt should have resulted in a penalty for his side.
Bogle's injury is less serious, but he will still miss this match to make it eight first-team players out for the rock-bottom Blades.
Indeed, the 33-year-old McGoldrick and 35-year-old Billy Sharp have combined for more than half of Sheffield United's league goals this season and could lead the line together for this one.
Sheffield United possible starting lineup: Ramsdale; Ampadu, Jagielka, Bryan; Baldock, Lundstram, Norwood, Fleck, Stevens; McGoldrick, Sharp
Watch the Sports Mole Football Shorts prediction for this game below: