Klopp's side were given a tougher time than expected in midweek against Villarreal, requiring a second-half fightback following an out-of-sorts opening 45 minutes to book their place in the final of the Champions League.
With every game from now until the season a must-win if Liverpool are to achieve an unprecedented quadruple, there are unlikely to be wholesale changes from the manager, but the more regular switches are expected.
However, with one eye potentially on next weekend's FA Cup final with Chelsea too, Klopp may instead view Tuesday's match against Aston Villa as a better opportunity to rest any tired legs, keeping Salah and Mane in the fold for this one.
Roberto Firmino is closing in on a return to fitness, having travelled with the team to Villarreal in midweek, but he did not make the squad for that match and is not expected to feature on Saturday either.
Liverpool's midfield in particular experienced a game of two halves in midweek, but even without that factor Klopp will have likely brought Jordan Henderson back into the fold for this game in order to keep his squad as fit as possible.
At the back, Joel Matip will continue his role as Premier League centre-back alongside Virgil van Dijk, with Ibrahima Konate - still unbeaten as a Liverpool player - being reserved for European games on the whole of late.
Behind them, Alisson Becker has already kept 20 clean sheets this season, and should he record shutouts in each of Liverpool's four remaining games then he would equal Petr Cech's record single-season tally.
Liverpool possible starting lineup: Alisson; Alexander-Arnold, Matip, Van Dijk, Robertson; Henderson, Fabinho, Thiago; Salah, Mane, Diaz