As well as a Champions League spot, revenge and redemption may also be on the agenda for Jurgen Klopp's side following their 7-2 hammering in the reverse fixture in October.
Here, Sports Mole rounds up the latest team news for both sides ahead of the contest.
Sports Mole's predicted XI: Alisson; Alexander-Arnold, Phillips, Kabak, Robertson; Milner, Fabinho, Jones; Shaqiri, Firmino, Mane
Sports Mole's predicted XI: Martinez; Cash, Konsa, Mings, Targett; Luiz, McGinn; Traore, Barkley, Trezeguet; Watkins
Watch the Sports Mole Football Shorts prediction for this game below: