Returning to an eventful Europa League journey, and leaving their domestic woes to one side, Manchester United will meet Athletic Bilbao at San Mames on Thursday.
Into yet another European semi-final, the Premier League giants will seek a precious lead ahead of next week's return leg, though their lineup options are somewhat limited by injuries.
While Ruben Amorim has Amad Diallo and Matthijs de Ligt available again, neither is likely to start; meanwhile, Toby Collyer and Ayden Heaven are ruled out.
Already missing Diogo Dalot, Joshua Zirkzee and Lisandro Martinez, Amorim may decide to make minimal changes to the team that started Sunday's 1-1 draw with Bournemouth.
After finally ending his long goal drought, Rasmus Hojlund is set to feature up front, while United captain Bruno Fernandes should again join Alejandro Garnacho in the Danish striker's supporting cast.
Kobbie Mainoo, Christian Eriksen and Mason Mount are also in the mix, but Manuel Ugarte and experienced campaigner Casemiro could be paired in central midfield.
Elsewhere, Luke Shaw's timely comeback from his latest long layoff might offer more balance to the Red Devils' leaky defence, allowing Noussair Mazraoui to operate out wide on the right.
Manchester United possible starting lineup: Onana; Yoro, Maguire, Shaw; Mazraoui, Ugarte, Casemiro, Dorgu; Fernandes, Garnacho; Hojlund
> Click here to see how Athletic Club could line up for Thursday's Europa League semi-final first leg body check tags ::
