Jose Mourinho welcomes former club Chelsea to North London in the pick of the Premier League gameweek 22 fixtures as an out-of-form Tottenham Hotspur side bid to end Thomas Tuchel's unbeaten start in charge of the Blues.
Leaders Manchester City will look to continue their ominous form away to Burnley, while Manchester United host Southampton and champions Liverpool welcome Brighton & Hove Albion to Anfield.
Click play below to watch or listen to Sports Mole Editor Barney Corkhill and Football Editor Matt Law discuss their predictions for all 10 midweek fixtures.
Watch the full discussion here:
Or you can listen to the full podcast here:
TUESDAY
6pm - Sheffield United vs. West Brom (0:12)
6pm - Wolverhampton Wanderers vs. Arsenal (4:40)
8.15pm - Manchester United vs. Southampton (9:18)
8.15pm - Newcastle United vs. Crystal Palace (14:49)
WEDNESDAY
6pm - Burnley vs. Man City (19:07)
6pm - Fulham vs. Leicester City (24:01)
7.30pm - Leeds United vs. Everton (28:53)
8.15pm - Aston Villa vs. West Ham United (33:09)
8.15pm - Liverpool vs. Brighton (38:25)
THURSDAY
8pm - Tottenham Hotspur vs. Chelsea (43:07)