Manchester United travel to Molineux to face Wolverhampton Wanderers - the side that knocked the Red Devils out of this competition at the quarter-final stage last season - in the FA Cup.
United were beaten 2-0 by Arsenal in their last outing, handing Gunners boss Mikel Arteta his first win as a head coach in the process.
The result leaves Ole Gunnar Solskjaer's side five points adrift of fourth-placed Chelsea in the Premier League table.
Here, Sports Mole rounds up United's latest injury and suspension news ahead of the cup clash.
Status: Out
Type of injury: Foot
Possible return date: Unknown
The World Cup winner is set for a foot operation and will be unavailable for the next few weeks or so, leaving United light on midfield options.
Status: Out
Type of injury: Knee
Possible return date: Unknown
The central defender has spent a substantial period on the sidelines and, despite being tipped to return around this time of year, it seems that his recovery may take a while longer.
Status: Out
Type of injury: Knee
Possible return date: January 19 (vs. Liverpool)
Fosu-Mensah is closing in on a return from a long-term knee injury and could be fit to feature again before the end of the month.
Status: Out
Type of injury: Knee
Possible return date: February 23 (vs. Watford)
The midfielder is set to be sidelined until late next month and Solskjaer has insisted that the youngster will not be rushed back.
Status: Out
Type of injury: Muscle
Possible return date: Unknown
Rojo is still working his way back from injury and should not be too far away from a comeback, but this game appears to have come too soon for the defender.
Status: Out
Type of injury: Thigh
Possible return date: Unknown
No timescale has yet been set for Tuanzebe's return following the hamstring injury he sustained last month.
MANCHESTER UNITED'S SUSPENSION LIST
United have no players suspended for this match.
