Manchester United will be without the services of Fred, Edinson Cavani, Luke Shaw, Scott McTominay and Raphael Varane through injury for Saturday's Premier League clash with Norwich City.
McTominay, Varane, Cavani and Shaw were all unavailable for selection against Everton last weekend, and interim head coach Ralf Rangnick has confirmed that they remain on the sidelines.
Fred, meanwhile, picked up a hip problem in the defeat to Everton, and the Brazil international will also be absent for the 20-time English champions at Old Trafford.
Mason Greenwood remains out through a club suspension, so the hosts will be without the services of six first-team players for the visit of Norwich.
Cristiano Ronaldo suffered a nasty gash to his shin against Everton last weekend, but the Portugal international has trained this week and is available for selection against Dean Smith's side.
Victor Lindelof, Nemanja Matic and Paul Pogba could benefit from the absences to make the starting XI this weekend, while Anthony Elanga and Diogo Dalot are pushing to return to the side.
Man United are currently seventh in the Premier League table, six points behind fourth-placed Tottenham Hotspur on the same number of matches (31).