The Brazil defender has not featured for the Blues since the 1-0 win at Tottenham on February 4 due to a thigh injury.
Boss Thomas Tuchel confirmed Silva should return to full training next week and has no other injury concerns ahead of the Stamford Bridge meeting.
Cavani and Van De Beek have missed the past three matches with muscle complaints, while McTominay has been absent since coming off 60 minutes into last week’s Europa League last-32 first-leg win against Real Sociedad.
Van de Beek trained on Friday but McTominay joins Paul Pogba on the sidelines, while Ole Gunnar Solskjaer says he is not optimistic about Cavani’s chances of making the game. Daniel James will be assessed after limping off in Thursday’s second leg and Solskjaer has confirmed Juan Mata will be out for a couple of weeks, joining Phil Jones (knee) and Hannibal Mejbri (shoulder) on the sidelines.
Chelsea provisional squad: Mendy, Azpilicueta, Christensen, Rudiger, Hudson-Odoi, Jorginho, Kovacic, Alonso, Mount, Werner, Giroud, Arrizabalaga, James, Zouma, Chilwell, Kante, Havertz, Ziyech, Pulisic, Abraham, Caballero, Emerson, Gilmour.
Manchester United provisional squad: De Gea, Henderson, Grant, Wan-Bissaka, Williams, Bailly, Lindelof, Maguire, Tuanzebe, Shaw, Telles, Matic, Van De Beek, Fred, Fernandes, Diallo, James, Shoretire, Greenwood, Martial, Rashford.