Crystal Palace vs. Spurs (Saturday, 12.30pm)
Premier League table-toppers Tottenham Hotspur will seek a fourth win from as many matches in Saturday's London derby with Crystal Palace at Selhurst Park.
Nuno Espirito Santo's side prevailed 1-0 against Watford before the international break, while Palace rescued a point in a 2-2 draw with West Ham United.
We say: Crystal Palace 1-1 Tottenham Hotspur
A wave of fresh injury and quarantine-related absences is hardly a recipe for success for Tottenham this weekend, while the farcical situation surrounding Lo Celso and Romero's Argentina-Brazil chaos is another matter entirely.
Spurs still have plenty of talent in their ranks capable of troubling a leaky Palace backline, but Vieira's new signings may now be starting to gel, and we can envisage a third consecutive 1-1 draw between the two sides at Selhurst Park as Spurs' perfect start comes to an end.
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> How Tottenham could line up against Crystal Palace
> Tottenham injury, suspension list vs. Crystal Palace
Arsenal vs. Norwich (Saturday, 3.00pm)
The Emirates Stadium plays host to a bottom-of-the-table Premier League encounter on Saturday lunchtime, as Arsenal face off against another pointless side in Norwich City.
The Gunners were torn apart by champions Manchester City before the international break, while Norwich suffered a 2-1 defeat to Leicester City.
We say: Arsenal 2-0 Norwich City
In what has been jokingly referred to as a relegation battle, Norwich may travel to the Emirates feeling optimistic about their chances of a shock result given their hosts' own abysmal start to the season.
However, Arsenal are set to welcome back a trio of indispensable players - with the returns of White and Gabriel undeniably key - and we are backing the Gunners to relieve the pressure on Arteta's shoulders with a first league win and clean sheet of the season.
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> How Arsenal could line up against Norwich City
> Arsenal injury, suspension list vs. Norwich
Brentford vs. Brighton (Saturday, 3.00pm)
Newly-promoted Brentford will be looking to maintain their unbeaten run in the Premier League when they host Brighton & Hove Albion on Saturday afternoon.
This will be the first top-flight meeting between the two sides, who have previously met in the second, third and fourth tiers of English football.
We say: Brentford 1-1 Brighton & Hove Albion
Both sides will view this fixture as a winnable game and they will been keen to build on their respective strong starts to the new campaign with another three points on Saturday.
However, a closely-fought contest is set to be played out at the Brentford Community Stadium, where we can see the spoils being shared.
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Leicester vs. Man City (Saturday, 3.00pm)
Manchester City will be looking to make it three straight Premier League victories when they resume their domestic campaign away to Leicester City on Saturday afternoon.
The Citizens have collected six points from their first three matches to sit seventh in the table, while Leicester have also picked up six points to occupy ninth after three rounds of fixtures in England's top flight.
We say: Leicester City 1-1 Manchester City
This is a very difficult match to call, as it is tough to predict what will occur after an international break, particularly one so early in the season. Man City will fancy their chances of making it three wins in a row, but Leicester will have some key players back this weekend, and we have had to settle on a low-scoring draw.
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> How Manchester City could line up against Leicester
> Man City injury, suspension list vs. Leicester
Man Utd vs. Newcastle (Saturday, 3.00pm)
Manchester United will be looking to record their third Premier League win of the season when they welcome Newcastle United to Old Trafford on Saturday afternoon.
The match is expected to mark the second debut of Cristiano Ronaldo, who incredibly returned to Old Trafford from Juventus in the final stages of the summer transfer window.
We say: Manchester United 3-1 Newcastle United
Newcastle will be far from at full strength on Saturday, and it is difficult to imagine them leaving Old Trafford with a positive result. Ronaldo's return has created a real buzz around Man United, and we are expecting the Portuguese to inspire his side to all three points this weekend.
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> How Man United could line up against Newcastle
> Man United injury, suspension list vs. Newcastle
> When could Cristiano Ronaldo make his second Man United debut?
Southampton vs. West Ham (Saturday, 3.00pm)
Seeking to maintain their unbeaten start to the new Premier League season, West Ham United travel south to meet Southampton on Sunday afternoon.
Both sides played out 2-2 draws just before the international break, with the Saints rescuing a point against Newcastle United while West Ham were pegged back by Crystal Palace.
We say: Southampton 1-2 West Ham United
West Ham do not do boring matches, and as impressive as they have been on the goalscoring front so far, their defensive frailties were exposed by Gallagher in gameweek three.
Southampton have been able to take several positives from an otherwise disappointing start to the season on paper, but they have struggled in this fixture down the years and may fall just short once again.
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Watford vs. Wolves (Saturday, 3.00pm)
Both Watford and Wolverhampton Wanderers will be looking to recover from defeats when they resume their respective Premier League campaigns with a clash at Vicarage Road on Saturday afternoon.
Watford suffered a 1-0 loss to Tottenham Hotspur before the international break, while Wolves, who are yet to get off the mark this term, were beaten 1-0 by Manchester United at Molineux.
We say: Watford 1-2 Wolverhampton Wanderers
Wolves will have been pleased with their performances this season despite suffering three defeats in the Premier League, and we are expecting their luck to change this weekend. It would not be a surprise to see a draw on Saturday, but we have just predicted the visitors to shade a close contest.
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Chelsea vs. Aston Villa (Saturday, 5.30pm)
Chelsea will be looking to return to winning ways in the Premier League when they welcome Aston Villa to Stamford Bridge on Saturday afternoon.
The Blues have collected seven points from their first three matches of the 2021-22 campaign to occupy fourth spot in the table, while Villa are in 11th with four points to show for their troubles thus far.
We say: Chelsea 2-1 Aston Villa
This is a tough game for Chelsea, who have had a lot of their key players away on international duty. Villa will be a serious threat going forward if both Watkins and Ings are in the starting XI, but we are still expecting the Blues to pick up all three points, albeit by the narrowest of margins.
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> How Chelsea could line up against Aston Villa
> Chelsea injury, suspension list vs. Aston Villa body check tags ::
