Burnley vs. Everton (Saturday, 12.30pm)
Burnley and Everton will both be looking to bounce back from disappointing defeats last time out when they meet at Turf Moor on Saturday lunchtime.
The Clarets were thrashed 5-0 by Manchester City in their most recent outing, while Everton went down 1-0 at home to Leeds United.
Eleven points separate the sides heading into this opening Premier League fixture of the weekend, with the Toffees in eighth and their opponents in the bottom three.
We say: Burnley 1-2 Everton
Everton have badly lost their way after a really strong start to the season and have an extremely tough run of games to come after this trip to Turf Moor.
If not quite must win, anything less than three points in Lancashire will be considered a poor result for the Toffees, who have aspirations of challenging for a European spot.
None of the 12 Premier League games between Burnley and Everton has been drawn - the Clarets winning five to the Toffees' seven - and we are going with an away win this weekend.
Our tipster partners are predicting over 1.5 goals.
> Click here to read our full preview for this match
Man City vs. Fulham (Saturday, 3.00pm)
Manchester City welcome Fulham to the Etihad Stadium on Saturday afternoon with both sides coming into the match off the back of much-needed Premier League victories.
The return of fans will have to wait in Manchester, but City at least have the chance to make a significant climb up the table as they host the newly-promoted Cottagers.
We say: Manchester City 3-0 Fulham
Fulham have massively improved at the back since the early weeks of the season, but a trip to face Man City at the Etihad Stadium remains one of the toughest tests in English football and we cannot see anything other than a comfortable home win.
The Cottagers should take huge confidence from Monday's win at Leicester, but with Man City having rediscovered their ruthless streak in front of goal last weekend we can see the hosts cruising to victory once again.
Our tipster partners are predicting that at least one team will not score (BTTS - no).
> Click here to read our full preview for this match
> How Man City could line up against Fulham
> Man City injury, suspension list vs. Fulham
West Ham vs. Man Utd (Saturday, 5.30pm)
Premier League fans will return for the first time since March when West Ham United host Manchester United at the London Stadium on Saturday afternoon.
Up to 2,000 supporters will be permitted to attend a fascinating contest between two sides separated by four places but just one point in the Premier League table.
We say: West Ham United 2-1 Manchester United
This will be only the fourth time in the Premier League era that West Ham go into a match against Manchester United sitting above their opponents in the table, and we are backing Moyes to extend that lead against his former club.
Man United's away form is nothing short of incredible, but West Ham have been impressive at home, have fared relatively well against the bigger teams and should be boosted by the long-awaited return of supporters too.
Our tipster partners are predicting a double chance bet on a draw or an away win.
> Click here to read our full preview for this match
> How Man United could line up against West Ham
> Man United injury, suspension list vs. West Ham
Chelsea vs. Leeds (Saturday, 8.00pm)
Up to 2,000 fans will be allowed into Stamford Bridge for the first league meeting between Chelsea and Leeds United since May 2004 on Saturday evening.
Chelsea boss Frank Lampard already has a storied history against Leeds as a manager, and he could add another chapter to that this weekend with victory enough to take his side temporarily top of the Premier League table.
We say: Chelsea 2-0 Leeds United
This promises to be another fascinating showdown between Lampard and Bielsa, and we are backing Chelsea to come out on top in front of their small section of returning supporters.
Leeds have the quality to cause Chelsea problems, but they have only scored three goals in their last four games whereas Chelsea's defence looks like the most reliable in the league right now.
Our tipster partners are predicting over 2.5 goals.
> Click here to read our full preview for this match