Sheff Utd vs. Spurs (Sunday, 2.00pm)
While the home side are nine points behind 17th-placed Brighton & Hove Albion, the midweek triumph over Newcastle United has given hope to Chris Wilder's team as they bid to avoid relegation.
We say: Sheffield United 1-3 Tottenham Hotspur
Mourinho cut a frustrated figure on Wednesday night, and we expect that to lead to a response from his players. Despite the Blades being on a high after edging out Newcastle, they may struggle to cope with Spurs' extra quality in the final third.
Our tipster partners are predicting under 3.5 goals.
Liverpool vs. Man Utd (Sunday, 4.30pm)
The biggest fixture in the English calendar will take on even more significance this weekend when champions Liverpool host new Premier League leaders Manchester United at Anfield.
The two most successful clubs in the history of English football currently occupy the top two positions in the table, separated by only three points heading into this mouth-watering Merseyside meeting.
We say: Liverpool 2-1 Manchester United
This is one of the most finely-poised meetings between these two great rivals in recent memory.
Liverpool, the dominant force in English football over the last year or so but suffering a slight blip now, take on a league-leading Manchester United side showing the first signs of restoring their former glories - it could hardly be set up better.
It is a match which could realistically go either way, but Liverpool's remarkable home record gives them the slight edge as far as we are concerned. Indeed, a showdown with their fiercest enemies, who have just knocked them off the top of the table, could be the perfect fixture to snap Klopp's side out of their recent malaise.
Either way, it promises to be an unmissable contest. These big games can often flatter to deceive, but Sunday's showdown looks unlikely to be one of those occasions.
Our tipster partners are predicting a double chance bet on a home win or an away win.
Man City vs. Crystal Palace (Sunday, 7.15pm)
We say: Manchester City 2-0 Crystal Palace
Palace deserve huge credit for their performance at Arsenal, and the Eagles will enter this weekend's contest in strong form. City are on a bit of a roll at the moment, though, and we are finding it difficult to back against Guardiola's side, who are now regarded by many to be the favourites for the title.
Our tipster partners are predicting over 2.5 goals.