Manchester United will be looking to make it back-to-back wins in the Premier League when they welcome West Ham United to Old Trafford on Sunday night.
The Red Devils, who recorded a 2-0 victory over Manchester City last weekend, will again be without Paul Pogba, Juan Mata and Phil Jones for this game, while Donny van de Beek is also incredibly unlikely to be available as he battles to overcome a muscular problem.
Ole Gunnar Solskjaer's side could also be missing Edinson Cavani as the experienced striker is struggling to overcome a knock, while Anthony Martial was forced off against AC Milan in the Europa League on Thursday night with a hip problem and is a major doubt.
Marcus Rashford also missed the draw with Milan due to the ankle problem that he picked up in the Manchester derby, but the England international could be available for selection against the Hammers.
There will be changes from Thursday's Europa League contest, with Victor Lindelof, Luke Shaw and Fred all expected to return.
David de Gea is back in Manchester after returning to Spain for the birth of his child, but the goalkeeper is currently self-isolating, meaning that Dean Henderson should retain his spot between the sticks.
Daniel James and Bruno Fernandes are set to feature in the final third, with Mason Greenwood potentially leading the line, while Amad Diallo, who scored on Thursday, could be in contention for a surprise start if Rashford is unable to prove his fitness.
Injuries have hit Solskjaer's squad at a key stage of the campaign, and the Red Devils will be far from at full strength against a West Ham side that are very much in the top-four battle.
Man United possible starting lineup: Henderson; Wan-Bissaka, Lindelof, Maguire, Shaw; Fred, McTominay; Rashford, Fernandes, James; Greenwood
> Click here to see how West Ham could line up for this contest
Video prediction
Watch the Sports Mole Football Shorts prediction for this game below: