The Argentina international took to Instagram on Sunday to announce that he will be departing the Turin side after seven years at the club.
"It is difficult to find the right words to greet you, there are so many years and so many emotions involved, all together, I thought we would be together even more years, but fate puts us on different paths," Dybala wrote.
"I will never forget everything you made me experience, every game, every goal. With you I grew up, I learned, I lived and I dreamed. It has been 7 years of magic, 12 trophies and 115 goals that no one will take away from us. Never.
"Thank you for supporting me in difficult times. Thanks to those who have accompanied me over the years: from the first to the last, from the fans to the people who work within the club, everyone, coaches and teammates, employees and managers.
"Wearing this important jersey together with the captain's armband has been one of the greatest pride of my life, which I hope to show to my children and grandchildren someday.
"Tomorrow will be my last match with this shirt, it's hard to imagine, but it will be our last farewell. It will not be easy, but I will enter the field with a smile and with my head held high, knowing that I have given everything for you."
Dybala will bid farewell to the Juventus faithful on Monday, with the Old Lady set to play host to Lazio in what will be the Argentine's final home game for the Bianconeri.