Both Anderson and Nani will reportedly depart Manchester United this month.
The duo arrived at Old Trafford as teenagers in the summer of 2007, but it is widely regarded that neither has gone on to fulfill the early potential that they displayed.
As a result, manager David Moyes is willing to part with the pair, with Brazilian midfielder Anderson close to signing for Serie A side Fiorentina, according to the Daily Mail.
Meanwhile, once he has recovered from injury, winger Nani will rejoin Sporting Lisbon, initially on a loan basis, according to the same report.
It is also thought that Wilfried Zaha will be allowed to leave on a temporary deal.