This East Midlands derby at the City Ground is one of the more eye-catching fixtures in this weekend's third round of the FA Cup.
While Leicester's promotion push has withered in recent weeks, Forest are flirting dangerously with relegation in the Championship.
Marlon Harewood could make his first appearance in eight years for the hosts following his free transfer from China.
Manager Steve Cotterill will also hope to have Joel Lynch, Paul Anderson and Dexter Blackstock back in the squad.
Meanwhile, the Foxes will be without the suspended Steve Howard after his sending off against Crystal Palace on Monday.
Gelson Fernandes is also unavailable for Nigel Pearson's side following the recent cancellation of his loan deal from French club Saint Etienne.
Forest came back from 2-0 down to earn a 2-2 draw against their local rivals when the two sides met in the league at the City Ground in August.
Current Form: Forest: LLDLLW Possible lineups: Forest: Camp; Cunningham, Chambers, Gunter, Moussi; Anderson, Leicester: Schmeichel; Mills, Bamba, Kennedy, Tunchev; Moore, Sports Mole says: 1-1
Leicester: LDLDDW
Greening, Boateng, McCleary; Blackstock, McGugan
Abe, Danns, Gallagher; King, Nugent